Toward the language oscillogenome

Language has been argued to arise, both ontogenetically and phylogenetically, from specific patterns of brain wiring. We argue that it can further be shown that core features of language processing emerge from particular phasal and cross-frequency coupling properties of neural oscillations; what has been referred to as the language 'oscillome.' It is expected that basic aspects of the language oscillome result from genetic guidance, what we will here call the language 'oscillogenome,' for which we will put forward a list of candidate genes. We have considered genes for altered brain rhythmicity in conditions involving language deficits: autism spectrum disorders, schizophrenia, specific language impairment and dyslexia. These selected genes map on to aspects of brain function, particularly on to neurotransmitter function. We stress that caution should be adopted in the construction of any oscillogenome, given the range of potential roles particular localized frequency bands have in cognition. Our aim is to propose a set of genome-to-language linking hypotheses that, given testing, would grant explanatory power to brain rhythms with respect to language processing and evolution.Economic and Social Research Council scholarship 1474910Ministerio de Economía y Competitividad (España) FFI2016-78034-C2-2-

Putting a Price Tag on the Common Core: How Much Will Smart Implementation Cost?

The Common Core State Standards (CCSS) for English language arts and mathematics represent a sea change in standards-based reform and their implementation is the movement's next -- and greatest -- challenge. Yet, while most states have now set forth implementation plans, these tomes seldom address the crucial matter of cost. Putting a Price Tag on the Common Core: How Much Will Smart Implementation Cost? estimates the implementation cost for each of the forty-five states (and the District of Columbia) that have adopted the Common Core State Standards and shows that costs naturally depend on how states approach implementation. Authors Patrick J. Murphy of the University of San Francisco and Elliot Regenstein of EducationCounsel LLC illustrate this with three models

Phasal Eliminativism, Anti-Lexicalism, and the Status of the Unarticulated

This paper explores the prospect that grammatical expressions are propositionally whole and psychologically plausible, leading to the explanatory burden being placed on syntax rather than pragmatic processes, with the latter crucially bearing the feature of optionality. When supposedly unarticulated constituents are added, expressions which are propositionally distinct, and not simply more specific, arise. The ad hoc nature of a number of pragmatic processes carry with them the additional problem of effectively acting as barriers to implementing language in the brain. The advantages of an anti-lexicalist biolinguistic methodology are discussed, and a bi-phasal model of linguistic interpretation is proposed, Phasal Eliminativism, carved by syntactic phases and (optionally) enriched by a restricted number of pragmatic processes. In addition, it is shown that the syntactic operation of labeling (departing from standard Merge-centric evolutionary hypotheses) is responsible for a range of semantic and pragmatic phenomena, rendering core aspects of syntax and lexical pragmatics commensurable

Linguistic Representation and Processing of Copredication

This thesis addresses the lexical and psycholinguistic properties of copredication. In particular, it explores its acceptability, frequency, crosslinguistic and electrophysiological features. It proposes a general parsing bias to account for novel acceptability data, through which Complex-Simple predicate orderings are degraded across distinct nominal types relative to the reverse order. This bias, Incremental Semantic Complexity, states that the parser seeks to process linguistic representations in incremental stages of semantic complexity. English and Italian acceptability data are presented which demonstrate that predicate order preferences are based not on sense dominance but rather sense complexity. Initial evidence is presented indicating that pragmatic factors centred on coherence relations can impact copredication acceptability when such copredications host complex (but not simple) predicates. The real-time processing and electrophysiological properties of copredication are also presented, which serve to replicate and ground the acceptability dynamics presented in the thesis

Toward the Language Oscillogenome

Language has been argued to arise, both ontogenetically and phylogenetically, from specific patterns of brain wiring. We argue that it can further be shown that core features of language processing emerge from particular phasal and cross-frequency coupling properties of neural oscillations; what has been referred to as the language ‘oscillome.’ It is expected that basic aspects of the language oscillome result from genetic guidance, what we will here call the language ‘oscillogenome,’ for which we will put forward a list of candidate genes. We have considered genes for altered brain rhythmicity in conditions involving language deficits: autism spectrum disorders, schizophrenia, specific language impairment and dyslexia. These selected genes map on to aspects of brain function, particularly on to neurotransmitter function. We stress that caution should be adopted in the construction of any oscillogenome, given the range of potential roles particular localized frequency bands have in cognition. Our aim is to propose a set of genome-to-language linking hypotheses that, given testing, would grant explanatory power to brain rhythms with respect to language processing and evolution

Natural Language Syntax Complies with the Free-Energy Principle

Natural language syntax yields an unbounded array of hierarchically structured expressions. We claim that these are used in the service of active inference in accord with the free-energy principle (FEP). While conceptual advances alongside modelling and simulation work have attempted to connect speech segmentation and linguistic communication with the FEP, we extend this program to the underlying computations responsible for generating syntactic objects. We argue that recently proposed principles of economy in language design - such as "minimal search" criteria from theoretical syntax - adhere to the FEP. This affords a greater degree of explanatory power to the FEP - with respect to higher language functions - and offers linguistics a grounding in first principles with respect to computability. We show how both tree-geometric depth and a Kolmogorov complexity estimate (recruiting a Lempel-Ziv compression algorithm) can be used to accurately predict legal operations on syntactic workspaces, directly in line with formulations of variational free energy minimization. This is used to motivate a general principle of language design that we term Turing-Chomsky Compression (TCC). We use TCC to align concerns of linguists with the normative account of self-organization furnished by the FEP, by marshalling evidence from theoretical linguistics and psycholinguistics to ground core principles of efficient syntactic computation within active inference

Hepatic encephalopathy impacts the predictive value of the Fried Frailty Index

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/146338/1/ajt15020.pdfhttps://deepblue.lib.umich.edu/bitstream/2027.42/146338/2/ajt15020_am.pd

Prevalence of vitamin D deficiency and association with metabolic syndrome in a Qatari population

Background/Objectives Despite long hours of sunlight in Qatar and other regions of the Middle East, vitamin D deficiency has been rising. In parallel, the prevalence metabolic syndrome has also been increasing in Qatar. Vitamin D levels have been associated with metabolic syndrome but data are inconsistent and no studies have addressed these inter-relationships in a Middle Eastern population where the prevalence of these conditions is high. The objective is to investigate the prevalence of vitamin D deficiency and its association with metabolic syndrome and its components in the Qatar Biobank population. Subjects/Methods A cross-sectional study of 1 205 participants (702 women and 503 men) from the Qatar Biobank, comprising Qataris and non-Qataris between the ages of 18 to 80 years, was used to perform multivariate linear regression analyses to examine the association between metabolic syndrome and prevalence of vitamin D deficiency (defined as <20 ng/mL serum vitamin D levels) adjusting for age, sex, ethnicity, season of blood collection, physical activity, and education. Odds ratios and 95% confidence intervals were calculated for all analyses. Results Approximately 64% of participants were vitamin D deficient (<20 ng/mL) with more men being deficient (68.6%) than women (61.3%). Serum vitamin D was 8% lower in individuals with metabolic syndrome (RR: 0.92, 95%CI: 0.87 – 0.98, p-value: 0.01) compared to individuals without metabolic syndrome. Waist circumference and HDL as well as high triglyceride levels were also significantly positively associated with vitamin D deficiency. No association was found between the other components of metabolic syndrome or diabetes and the presence of vitamin D deficiency. Conclusions Vitamin D deficiency is prevalent in this Qatari population. Presence of metabolic syndrome was associated with presence of vitamin D deficiency. Future prospective studies need to be conducted to investigate the potential for causality

Selection of Depression Measures for Use among Vietnamese Populations in Primary Care Settings: A Scoping Review

Depression is an important and growing contributor to the burden of disease around the world and evidence suggests the experience of depression varies cross-culturally. Efforts to improve the integration of services for depression in primary care are increasing globally, meaning that culturally valid measures that are acceptable for use in primary care settings are needed. We conducted a scoping review of 27 studies that validated or used 10 measures of depression in Vietnamese populations. We reviewed the validity of the instruments as reported in the studies and qualitatively assessed cultural validity and acceptability for use in primary care. We found much variation in the methods used to validate the measures, with an emphasis on criterion validity and reliability. Enhanced evaluation of content and construct validity is needed to ensure validity within diverse cultural contexts such as Vietnam. For effective use in primary care, measures must be further evaluated for their brevity and ease of use. To identify appropriate measures for use in primary care in diverse populations, assessment must balance standard validity testing with enhanced testing for appropriateness in terms of culture, language, and gender and for acceptability for use in primary care